Ruz M, Carrasco F, Rojas P, et al. Enteral zinc supplementation in preterm or low birth weight infants: a systematic review and meta-analysis. View abstract. It may also interfere with the absorption of copper and reduce the effectiveness of certain antibiotics. Zinc supplement use and risk of prostate cancer. Fertil Steril 1999;71:1138-43. Fairbrother, K. J., Kowolik, M. J., Curzon, M. E., Muller, I., McKeown, S., Hill, C. M., Hannigan, C., Bartizek, R. D., and White, D. J. Oral zinc sulphate in rheumatoid arthritis. Oral zinc therapy in recurrent erythema nodosum leprosum: a clinical study. View abstract. Pierard-Franchimont C, Goffin V, Visser JN, et al. 2005;24(6):979-987. Wang X, Wu W, Zheng W, et al. Golik, A., Cohen, N., Ramot, Y., Maor, J., Moses, R., Weissgarten, J., Leonov, Y., and Modai, D. Type II diabetes mellitus, congestive heart failure, and zinc metabolism. View abstract. Am J Clin Nutr 1992;56:148-57. J Am Coll Nutr 1994;13:479-84.. View abstract. JPed 1938;18:60-2. View abstract. Inter-relationship of zinc levels in serum and semen in oligospermic infertile patients and fertile males. Ann Intern Med 1984;100(3):367-371. View abstract. Clin Toxicol (Phila) 2006;44:135-41. Licastro F, Chiricolo M, Mocchegiani E, et al. Green S. Chelation therapy: unproven claims and unsound theories. View abstract. If you have questions about side effects, call your doctor. Trace elements during 2 years' oral contraception with low-estrogen preparations. J Pediatr Gastroenterol.Nutr 1987;6(2):296-301. Prasad, A. S. and Cossack, Z. T. Zinc supplementation and growth in sickle cell disease. 2013 17 ). For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Curr Ther Res 21986;39:19-29. Br J Dermatol 1979;101:321-5. Kajanachumpol, S., Srisurapanon, S., Supanit, I., Roongpisuthipong, C., and Apibal, S. Effect of zinc supplementation on zinc status, copper status and cellular immunity in elderly patients with diabetes mellitus. Mol Cell Biochem 1998;188:63-9. Peirce A. Mocchegiani E, Veccia S, Ancarani F, et al. To reduce your risk of side effects, stick to the recommended dosage and avoid exceeding the tolerable upper limit of 40 mg per day, unless under medical supervision. Zinc aspartate, biotin, and clobetasol propionate in the treatment of alopecia areata in childhood. Schisterman EF, Sjaarda LA, Clemons T, et al. View abstract. Funct Neurol. Comparison of oral treatment with zinc sulphate and placebo in acne vulgaris. J Nutr 2000 130:2251-5.. View abstract. View abstract. Acta Med Scand. Gupta, R., Garg, V. K., Mathur, D. K., and Goyal, R. K. Oral zinc therapy in diabetic neuropathy. Ayatollahi H, Rajabi E, Yekta Z, Jalali Z. Efficacy of oral zinc sulfate supplementation on clearance of cervical human papillomavirus (HPV); a randomized controlled clinical trial. Valberg LS, Flanagan PR, Chamberlain MJ. The effect of zinc sulfate in the prevention of high-dose chemotherapy-induced mucositis: a double-blind, randomized, placebo-controlled study. Br J Dermatol 1984;111:461-8. B., and Campa, A. Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Endocr Metab Immune Disord Drug Targets. Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Lovell MA, Robertson JD, Teesdale WJ, et al. View abstract. View abstract. View abstract. Am J Hematol. Anesth Analg. Colorectal Dis. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. Pediatrics 2007;120(4):e846-e855. Nutrients 2022;14(5):1055. View abstract. Antioxidant supplement and long-term reduction of recurrent adenomas of the large bowel. 5-16-2005;182(10):530-535. Factors affecting zinc homeostasis. Physiol Behav 2001;72:291-6.. View abstract. Oral Health Prev Dent. BMJ 1985;290:603-4. Fatal deterioration of Wilson's disease after institution of oral zinc therapy. 1980;7(4):309-315. Safety and efficacy of zinc supplementation for children with HIV-1 infection in South Africa: a randomised double-blind placebo-controlled trial. Mahyar A, Ayazi P, Ahmadi NK, et al. J Pediatr.Gastroenterol.Nutr 2006;43(3):357-363. Academic Press, New York, 1976. View abstract. View abstract. View abstract. Respir Care. 2014 May;51(5):375-8. View abstract. 2020;30(8):1260-1271. 2004;80(3):729-736. Scand J Rheumatol 1982;11:168-70. 2016;124(1):28-33. View abstract. 2014 Jan-Feb;22(1):52-7. Arch Ophthalmol 2001;119:1417-36. Arch Androl 1981;7(1):69-73. Obstet Gynecol 1987;69:26-32. Pregnancy complications in people with HIV/AIDS. Biol Trace Elem Res 1998;61:19-31. View abstract. Ann Intern Med 2000;133:302-3. However, its important not to exceed the upper limit of 40 mg of zinc per day, as consuming high amounts could cause digestive issues and flu-like symptoms, decrease copper absorption, and reduce the effectiveness of certain antibiotics. Serum and hair zinc levels in epileptic children taking valproic acid. Age Ageing 1998;27:715-22. Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 years: randomised controlled trial in an urban slum. Zinc supplements are generally well tolerated, though theyve been associated with adverse side effects like nausea, vomiting, diarrhea, and stomach pain in some people (1). View abstract. Esmaeli, B., Burnstine, M. A., Martonyi, C. L., Sugar, A., Johnson, V., and Brewer, G. J. Regression of Kayser-Fleischer rings during oral zinc therapy: correlation with systemic manifestations of Wilson's disease. Discover foods high in zinc, like shellfish, nuts. New York, NY: William Morrow and Co., 1999. BMC.Public Health 2011;11 Suppl 3:S23. Phase I trials of dexrazoxane and other potential applications for the agent. Ducray A, Bondier JR, Michel G, et al. Minerals. View abstract. Sur, D., Gupta, D. N., Mondal, S. K., Ghosh, S., Manna, B., Rajendran, K., and Bhattacharya, S. K. Impact of zinc supplementation on diarrheal morbidity and growth pattern of low birth weight infants in kolkata, India: a randomized, double-blind, placebo-controlled, community-based study. Med J Indonesia 1998;7:237-241. Hyun TH, Barrett-Connor E, Milne DB. Acta Ophthalmol. View abstract. View abstract. Controlled trial of D-penicillamine in rheumatoid arthritis. Fischer Walker, C. L., Bhutta, Z. Nail molybdenum and zinc contents in populations with low and moderate incidence of esophageal cancer. Available at: https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/287/insti-drug-interactions. View abstract. View abstract. The results of a 2017 randomized trial suggest artificial sweeteners may increase BMI, weight, metabolic syndrome and type 2 diabetes, although more information is needed to be conclusive. Chemistry of dexrazoxane and analogues. Brooks, W. A., Santosham, M., Roy, S. K., Faruque, A. S., Wahed, M. A., Nahar, K., Khan, A. I., Khan, A. F., Fuchs, G. J., and Black, R. E. Efficacy of zinc in young infants with acute watery diarrhea. Use of topical ascorbic acid and its effects on photodamaged skin topography. View abstract. Curr Health Sci J 2020;46(3):250-4. King JC. The effect of zinc supplementation on glucose homeostasis: a randomised double-blind placebo-controlled trial. Nutrition. Am J Hematol 1999;61:194-202. Clin Nutr Res. However, there are also side effects to consider. The side effects of artificial sweeteners may include: digestive issues, increased blood sugar levels, a higher risk of cancer, increased blood pressure and adverse effects on those with pre-existing mood disorders. View abstract. View abstract. David TJ, Wells FE, Sharpe TC, et al. View abstract. Pharmacol Toxicol 1989;65:209-13. Golik A, Modai D, Averbukh Z, et al. View abstract. Gupta VL, Chaubey BS. Arch Ophthalmol 1996;114:991-7. Ann NY Acad Sci 1992;669:314-6. Zinc metabolism in non-insulin dependent diabetes mellitus. Lazzerini, M. and Ronfani, L. Oral zinc for treating diarrhoea in children. U.S. Food and Drug Administration, June 16, 2009. Intake of vitamin C and zinc and risk of common cold: a cohort study. Is molluscum contagiosum related to zinc deficiency in children? Making matters worse, Susan developed chronic sinus and ear infections. Long-term swelling (inflammation) in the digestive tract (inflammatory bowel disease or IBD). High folate intakes related to zinc status in preterm infants. Sexual problems that prevent satisfaction during sexual activity. View abstract. Arch Otolaryngol Head Neck Surg 1999;125:1091-8. Akram M, Sullivan C, Mack G, Buchannan N. What is the clinical significance of reduced manganese and zinc levels in treated epileptic patients? Washington, DC: National Academy Press, 1999. Effect of zinc supplementation on clinical course of acute diarrhoea. BMC Pregnancy Childbirth. 1990;9(3):214-225. View abstract. 2003;10(5):324-329. View abstract. Academic Press, New York, 1976. pp51-65. 2001;19(4):339-346. Irfan O, Black RE, Lassi ZS, Bhutta ZA. AIDS 1999;13:495-500. Clin Exp Dermatol 1997;22:169-73. Med Oral Patol Oral Cir Bucal 2020;25(6):e791-8. Effects on metabolism. Donangelo CM, Woodhouse LR, King SM, et al. View abstract. View abstract. She developed various zinc toxicity symptoms, especially neurological problems, including an unsteady gait, dizziness, and a low white blood cell count. Eur.J Clin Nutr 1998;52(1):34-39. Threshold effects and interactive effects of total zinc and selenium intake on cognitive function in older adults. Am J Clin Nutr. Brooks, W. A., Santosham, M., Naheed, A., Goswami, D., Wahed, M. A., Diener-West, M., Faruque, A. S., and Black, R. E. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial. One 2014 study in 72 people with AMD showed that taking 50 mg of zinc sulfate daily for 3 months slowed the progression of the disease (23). Acta Derm Venereol 1992;72:250-2. Zinc supplements have also been seen to be effective in shortening cold symptoms, reduce the severity of cold sores, increase energy levels, treat ADHD in children, fighting hair loss and managing conditions such as hypoglycemia and diabetes. It is found in ordinary foods that we take such as red meat, sea foods and poultry. Wray D. A double-blind trial of systemic zinc sulfate in recurrent aphthous stomatitis. Methylphenidate for children and adolescents with autism spectrum disorder. Rossander-Hulten L, Brune M, Sandstrom B, et al. O'Brien KO, Zavaleta N, Caulfield LE, et al. View abstract. 2005;9(12):1378-1384. View abstract. Am J Clin Nutr 2008;87(5):1224-1229. 5 Vitamins and Minerals to Boost Your Metabolism and Promote Weight Loss. Anandhi P, Sharief RM, Rahila C. The Benefit of Zinc Sulfate in Oropharyngeal Mucositis during Hyperfractionated Accelerated Concomitant Boost Radiotherapy with Concurrent Cisplatin for Advanced-Stage Oropharyngeal and Hypopharyngeal Cancers. 1996;20(5):457-462. Digestion 1992;51:18-26. Arch.Intern.Med 11-10-1997;157(20):2373-2376. Leonard MB, Zemel BS, Kawchak DA, et al. Zinc in ulcerative colitis: a therapeutic trial and report on plasma levels. Klin.Wochenschr. Orbak, R., Cicek, Y., Tezel, A., and Dogru, Y. Int J Food Sci Nutr 2001;52:379-82.. View abstract. 1985;19(1):97-100. Effects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depression. 2014 Jun;33(3):415-20. Chung, C. S., Stookey, J., Dare, D., Welch, R., Nguyen, T. Q., Roehl, R., Peerson, J. M., King, J. C., and Brown, K. H. Current dietary zinc intake has a greater effect on fractional zinc absorption than does longer term zinc consumption in healthy adult men. View abstract. 1-1-2004;58(1):167-174. View abstract. Lancet 1971;2:1169-72. Effect of intragastric pH on the absorption of oral zinc acetate and zinc oxide in young healthy volunteers. View abstract. Lopez de Romana D, Lonnerdal B, Brown KH. View abstract. Indian Pediatr. Biol Trace Elem Res 2020 Nov 27:1-5. doi: 10.1007/s12011-020-02512-1. View abstract. Moore, R. Bleeding gastric erosion after oral zinc sulphate. Biol Psychiatry. Am J Dermatopathol 1992;14:304-9. Zinc toxicity. Faruque AS, Mahalanabis D, Haque SS, et al. Cochrane Database Syst Rev. Luabeya, K. K., Mpontshane, N., Mackay, M., Ward, H., Elson, I., Chhagan, M., Tomkins, A., Van den Broeck, J., and Bennish, M. L. Zinc or multiple micronutrient supplementation to reduce diarrhea and respiratory disease in South African children: a randomized controlled trial. Zinc can decrease the amount of tetracyclines the body absorbs. Int J Tuberc.Lung Dis. Zhou JR, Erdman JW Jr. Phytic acid in health and disease. 1997;55(3):82-85. Zittel S, Ufer F, Gerloff C, Mnchau A, Rosenkranz M. Severe myelopathy after denture cream use--is copper deficiency or excess zinc the cause? View abstract. View abstract. Zinc and immunity. 2016;24(4):331-336. If you are not much into meats or seafood, other good sources include beans, whole grains, dairy products, cereals and nuts. George J, Bhatia VN, Balakrishnan S, Ramu G. Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states. View abstract. View abstract. Jimenez E, Bosch F, Galmes JL, Banos JE. Sazawal, S., Black, R. E., Ramsan, M., Chwaya, H. M., Dutta, A., Dhingra, U., Stoltzfus, R. J., Othman, M. K., and Kabole, F. M. Effect of zinc supplementation on mortality in children aged 1-48 months: a community-based randomised placebo-controlled trial. J.Pediatr. 2020;197(2):394-404. View abstract. Mulder TP, van der Sluys Veer A, Verspaget HW, et al. View abstract. Am J Med Sci 1986;292(6):344-349. Ann Pharmacother 1995;29;1302. The effect of staggered administration of zinc sulfate on the pharmacokinetics of oral cephalexin. Polk RE, Healy DP, Sahai J, et al. Clemmensen OJ, Siggaard-Andersen J, Worm AM, et al. 2014;2014(9):CD001273. Ophthalmology. Beitr.Infusionsther. Kumar M, Swarnim S, Khanam S. Zinc Supplementation for prevention of febrile seizures recurrences in children: A systematic review and meta-analysis. Cisplatin is used to treat cancer. Arch Neurol. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. View abstract. 2007;46(4):427-430. View abstract. Study of immune function of cancer patients influenced by supplemental zinc or selenium-zinc combination. Call your doctor or get medical A type of zinc called zinc sulfate has been proven especially useful for decreasing symptoms of mild to moderate acne (16). Am J Clin Nutr 2001;73:1045-51. Taking zinc by mouth does not seem to reduce the risk of getting prostate cancer. View abstract. Zinc deficiency in mild hypertensive patients treated with diuretics. Hill, G. M., Brewer, G. J., Juni, J. E., Prasad, A. S., and Dick, R. D. Treatment of Wilson's disease with zinc. Within my practice, common artificial sweetener side effects include diarrhea, abdominal pain, joint pain, cramping, a burning sensation while urinating, constipation, and headaches. Vehapoglu A. Evaluation of oral zinc sulfate effect on obsessive-compulsive disorder: a randomized placebo-controlled clinical trial. That makes sugar-free sweeteners popular among people with diabetes, who need to monitor blood sugar levels closely. But this isn't likely to be a big concern for most people. Acne. Altunbasak S, Biatmakoui F, Baytok V, et al. Camacho FM, Garcia-Hernandez MJ. Gutierrez, Castrellon P., Polanco, Allue, I, and Salazar, Lindo E. [An evidence based Iberic-Latin American guideline for acute gastroenteritis management in infants and prescholars]. View abstract. Lewis-Jones MS, Evans S, Culshaw MA. View abstract. Taking zinc by mouth seems to help improve symptoms of this condition. Biol Trace Elem Res. Sharquie, K. E., Najim, R. A., Farjou, I. View abstract. 2014 Jun;121:17-8. J.Pediatr. Zinc supplementation in young children with acute diarrhea in India. Taking zinc by mouth does not appear to prevent diarrhea or death in people with this condition. if(typeof ez_ad_units != 'undefined'){ez_ad_units.push([[300,250],'healthifybody_com-banner-1','ezslot_3',125,'0','0'])};__ez_fad_position('div-gpt-ad-healthifybody_com-banner-1-0');if(typeof ez_ad_units != 'undefined'){ez_ad_units.push([[300,250],'healthifybody_com-banner-1','ezslot_4',125,'0','1'])};__ez_fad_position('div-gpt-ad-healthifybody_com-banner-1-0_1'); .banner-1-multi-125{border:none !important;display:block !important;float:none !important;line-height:0px;margin-bottom:7px !important;margin-left:auto !important;margin-right:auto !important;margin-top:7px !important;max-width:100% !important;min-height:250px;padding:0;text-align:center !important;}In terms of zinc toxicity, there is no other way to put it: excess zinc is dangerous! J Nutr 1994;124:1060-4. Int Urol Nephrol 1997;29:565-74. Eur J Dermatol 2000 May;10:269-73. Heyneman CA. Clin Nephrol. Eby GA, Halcomb WW. Study group of zinc acexamate]. BMJ 2002;324:1358. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Hustead, V. A., Greger, J. L., and Gutcher, G. R. Zinc supplementation and plasma concentration of vitamin A in preterm infants. Bioavailability of orally administered zinc, using Taurizine. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates. Absence of a therapeutic effect of zinc in the sexual dysfunction of haemodialysed patients Lancet 1980;2:618-20. Clin Nephrol 1982;17:254-7. View abstract. View abstract. Am J Med Sci 1981;282:68-74. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Lind, T., Lonnerdal, B., Stenlund, H., Gamayanti, I. L., Ismail, D., Seswandhana, R., and Persson, L. A. Available in capsule, tablet, and lozenge form, there are plenty of options to get your daily dose of zinc regardless of the type you choose. Clin Rheumatol 1998;17:378-82. Scholl, T. O., Hediger, M. L., Schall, J. I., Fischer, R. L., and Khoo, C. S. Low zinc intake during pregnancy: its association with preterm and very preterm delivery. JAMA 1990;264:1441-3. Hydrochlorothiazide-amiloride causes excessive urinary zinc excretion. View abstract. Rare side effects have also been reported and these include fever, sore throat, mouth sores, weakness and fatigue. Select a condition to view a list of vitamins. Am J Clin Nutr 1987;46:835-9. 1997;34(7):589-597. In as little as 24 hours, symptoms will begin to improve. Physiol Behav 1993;53:587-92. Sinha B, Dudeja N, Chowdhury R, et al. View abstract. A double-blind randomized trial. 2020;12(7):389-398. Wilkinson EAJ. Effect of a chelating drug on balance and tissue distribution of four essential metals. Chronic nutritional imbalance caused by taking too much zinc is a relatively common problem. Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein. HIV/AIDS. Potential side. Prasad AS. Association between zinc intake and risk of digestive tract cancers: a systematic review and meta-analysis. 2005-2023 Healthline Media a Red Ventures Company. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. View abstract. View abstract. View abstract. J Nutr 1989;119:48-53. View abstract. View abstract. J Gastroenterol 2013;48(6):698-705. Cunliffe WJ, Burke B, Dodman B, Gould DJ. Recovery following peripheral destruction of olfactory neurons in young and adult mice. J Am Coll Nutr 1982;1:207-14. Am J Clin Nutr. By the end of the six-month study, those drinking the diet soda weighed 17-21% less, had 24-31% less belly fat, 32% lower cholesterol levels, and 10-15% lower blood pressure, compared with those. Effects of zinc supplementation on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Sandstead HH. Necrolytic acral erythema associated with hepatitis C effective treatment with interferon alfa and zinc. Ethambutol and the eye: zinc and copper (letter). Spanish Study Group on NSAID Induced Gastroenteropathy Prevention. Association of zinc and antioxidant nutrients with age-related maculopathy. Serum and hair trace element levels in patients with epilepsy and healthy subjects: does the antiepileptic therapy affect the element concentrations of hair? Mathur NK, Bumb RA, Mangal HN, Sharma ML. 2012 Sep;28(9):892-5. View abstract. Brody I. Topical treatment of recurrent herpes simplex and post-herpetic erythema multiforme with low concentrations of zinc sulphate solution. FREE delivery Mon, Feb 13 on $25 of items shipped by Amazon. McCall JT, Goldstein NP, Randall RV, Gross JB. Effect of zinc supplementation on early outcome of neonatal sepsis--A randomized controlled trial. placebo-controlled trial. Here are 16 foods that are rich in, Zinc is involved in many important processes in your body and absolutely essential for good health. Uysal Z, Akar N, Kemahli S, et al. Sazawal, S., Black, R. E., Bhan, M. K., Jalla, S., Sinha, A., and Bhandari, N. Efficacy of zinc supplementation in reducing the incidence and prevalence of acute diarrhea--a community-based, double-blind, controlled trial. View abstract. Taking zinc by mouth might help to improve. J Nutr 2000;130:1488S-92S. Some research suggests that zinc may help keep blood sugar levels steady and improve your bodys sensitivity to insulin. View abstract. Calories, carbs, fat, protein, fiber, cholesterol, and more for Zing Stevia Sweetener ( Born Sweet). Taneja, S., Bhandari, N., Rongsen-Chandola, T., Mahalanabis, D., Fontaine, O., and Bhan, M. K. Effect of zinc supplementation on morbidity and growth in hospital-born, low-birth-weight infants. Ironically, many Chronic Kidney Disease and Diabetic patients avoid artificial sweeteners because of popularized studies describing how the sweeteners lead to Gastrointestinal (stomach) problems, Migraines, Seizures, Dizziness, Blurred vision, Allergic reactions, Blood sugar increases, and even Weight gain. Brown N, Kukka AJ, Mårtensson A. Efficacy of zinc as adjunctive pneumonia treatment in children aged 2 to 60 months in low-income and middle-income countries: a systematic review and meta-analysis. Taking zinc by mouth does not seem to help treat IBD. Patro, B., Szymanski, H., and Szajewska, H. Oral zinc for the treatment of acute gastroenteritis in Polish children: a randomized, double-blind, placebo-controlled trial. Charoenngam N, Ponvilawan B, Ungprasert P. Higher zinc intake is associated with decreased risk of lung cancer. View abstract. Inorganic zinc and the intestinal absorption of ferrous iron. View abstract. View abstract. AREDS report no. View abstract. Arch.Dis.Child 2006;91(4):296-299. Eur J Neurosci 2002;15:1907-17. 2017 Dec 20;12(12):CD010470. View abstract. Quintessence Int. Am J Clin Nutr 2004;80:715-21. J Child Psychol Psychiatry 1996;37:225-7.. View abstract. advice about side effects. View abstract. 2021;5(12):2001-8. N Engl J Med 1995;333:839-44. View abstract. View abstract. 2015;31(11-12):1358-61. View abstract. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:181-90.. View abstract. View abstract. J Clin Pathol 1998;41:553-5. The effect of zinc supplementation on blood pressure: a systematic review and dose-response meta-analysis of randomized-controlled trials. Treatment of valproate-induced alopecia (letter). View abstract. Consider consulting with a healthcare professional if symptoms persist. Randomized placebo-controlled clinical trial of zinc and copper ( letter ) letter ) children a! 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