phenylephrine injection for priapism cpt codephenylephrine injection for priapism cpt code
Following an intravenous infusion of phenylephrine hydrochloride, the observed effective half- life was approximately 5 minutes. Early identification of this diagnosis, as well as the sub-type of priapism, allows for rapid initiation of indicated treatments. Ultimately, clinical judgment is required to determine if any specific therapy is warranted versus additional observation. Panel members received no remuneration for their work. During Phenylephrine Hydrochloride Injection administration: The following are the recommended dosages for the treatment of hypotension during anesthesia. As the natural history of untreated acute ischemic priapism includes days to weeks of painful erections followed by permanent loss of erectile function, the condition requires prompt evaluation and may require emergency management. There were decreased caudal sperm density and increased abnormal sperm reported in males treated with 3 mg/kg/day phenylephrine (2.9 times the HDD). Urol Ann 2016; Bertolotto M, Zappetti R, Pizzolato R et al: Color doppler appearance of penile cavernosal-spongiosal communications in patients with high-flow priapism. We provide complete 24*7 Maintenance and Support Services that help customers to maximize their technology investments for optimal business value and to meet there challenges proficiently. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. A total of 17 observational studies were included (n=62 patients in total), of which two were moderate and 15 were low quality.19, 21, 30, 46, 49, 54, 55, 62-71 Specific protocols for managing priapism varied among the studies, including different utilizations of aspiration, irrigation, and ICI therapy; specific distal shunt performed; and number of prior attempted shunts. If a patient experiences a prolonged erection 1-4 hours after home ICI or following an in-office injection, they may be treated with conservative options (in the case of home ICI) or in-office phenylephrine. The optimal method for diagnosing priapism and differentiating acute ischemic priapism versus NIP subtypes has not been defined. Forward and backward mapping allows for easy transition between code sets. Understanding the history of the episode of priapism is important as history and etiology may determine the most effective treatment. All patients, regardless of duration, were refractory to aspiration and ICI and subsequently underwent distal shunting with tunneling. Although the incidence rate is relatively low, because of its time-dependent and progressive nature, priapism is a situation that both urologists and emergency medicine practitioners must be familiar with and comfortable managing. Searches identified 2948 potentially relevant articles, and 2516 of these were excluded at the title or abstract level for not meeting inclusion criteria for any key question. Preventative medical and interventional strategies for stuttering priapism, especially in the sickle cell population. Ask and when to ask some important questions to ask before accepting a new job Teach English abroad: Traveling. The objective of the current Guideline is to provide a practical guide that is directive in cases where evidence is more abundant while remaining flexible to allow for clinician judgment. this was great helped me do my first priapism drainage..! A Clinical Principle is a statement about a component of clinical care that is widely agreed upon by urologists or other clinicians for which there may or may not be evidence in the medical literature. After relief of acute priapism management of the underlying condition should prevent recurrence in all but SCD. However, PDUS been shown to be effective in assessing blood flow in many clinical conditions and is an option in a diagnostic setting to differentiate between acute ischemic and NIP.17, 72 Unfortunately, its use is limited by the number of specialists who can currently perform the procedure. Steps for aspiration/irrigation with phenylephrine administration: Acute Ischemic Priapism Panel, Consultants, and Staff. WebPhenylephrine is less effective in priapism of more than 48 hours because ischemia and acidosis impair the intracavernous smooth muscle response to sympathomimetics. The authors noted that distal perforation can occur in up to 6% of patients who have undergone previous shunt surgery. The medium risk of bias category is broad, and studies with this rating vary in their strengths and weaknesses. There may be some basis for these therapies, however, in the absence of any clinical data demonstrating efficacy, the Panel is unable to endorse their routine use (see Statement 22). PMID: Your email address will not be published. J Urol 1996; Gbadoe AD, Atakouma Y, Kusiaku K et al: Management of sickle cell priapism with etilefrine. In contrast to acute ischemic priapism, the non-ischemic variant is not considered a medical emergency. In general, evidence based solely on case series was graded very low due to the limitations of this study design, in particular the lack of a control group and inability to control for confounders or determine causality. One factor which may be used to determine whether intervention is appropriate is the extent of penile rigidity. All patients should be instructed at the time of ICI training, or after receiving an in-office erectogenic therapy, that they should return to either the office or emergency department if they experience an erection lasting longer than 4 hours. Low-flow priapism: dark blood with hypoxia, hypercapnia, and acidosis; High-flow priapism: bright red blood with normal arterial values; Doppler ultrasound. The recommended initial dose is 40 to 100 mcg administered by intravenous bolus. Korean J Urol 2014; Habous M, Elkhouly M, Abdelwahab O et al: Noninvasive treatments for iatrogenic priapism: Do they really work? J Sex Med 2008; Baba Y, Hayashi S, Ueno K et al: Superselective arterial embolization for patients with high-flow priapism: Results of follow-up for five or more years. In general, the Panel felt that it was not appropriate for clinicians who administer in-office erectogenic medications to refer the patient to the emergency department as a matter of routine following an in-office injection, rather, the patient should return to the office for detumescence whenever possible. In one notable study, T2-weighted gadolinium-enhanced MRI demonstrated 100% sensitivity in identifying non-viable corporal smooth muscle and which predicted future erectile dysfunction.5 However, given the time sensitivity of ischemic priapism diagnosis and management, MRI likely does not have a role in the initial diagnostic and treatment phase of priapism. Ask and when to ask yourself before 14 questions to ask before the! The Panel felt that it was important to highlight a clinicians responsibility in managing office-based erectogenic therapies. J Sex Med 2019; Pal DK, Biswal DK and Ghosh B: Outcome and erectile function following treatment of priapism: An institutional experience. Withdraw 10 mg (1 mL of 10 mg/mL) of phenylephrine hydrochloride and dilute with 99 mL of 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP. Early placements more often involved malleable devices, whereas malleable and inflatable versions were more evenly distributed in delayed placement studies. This latter observation would suggest a role for preventative measures to reduce distal perforation, although available data are lacking to suggest an optimal technique at the present time. Ultrasonography is of particular benefit in a patient with NIP being considered for fistula embolization. J Urol 1994;151: 878-9. In contemporary practice, prolonged erections often present in distinct virtual clinical settings, including during telephone conversations, text messages, and other similar scenarios. J Pediatr Surg 2005; Pieri S, Agresti P, La Pera G et al: Post-traumatic high flow priapism percutaneously treated with transcatheter embolisation. PMID: Priyadarshi S. Oral terbutaline in the management of pharmacologically induced prolonged erection. Diagnosed NIP is not a medical emergency. The range of reported recurrences also varied widely (0-100%), which underscores the poor reliability of the data overall. Answer:You should report this with 54220 (Irrigation of corpora cavernosa for priapism) instead of an unlisted code and 54235 (Injection of corpora cavernosa with pharmacologic agent[s]). The studies also represented very heterogeneous cohorts and included men with fistulae from prior trauma, surgical procedures, and cases of recurrence following failed prior embolizations. Cent European J Urol 2011; Chary KS, Rao MS, Kumar S et al: Creation of caverno-glandular shunt for treatment of priapism. Repetitive bedside irrigation procedures may, in theory, increase the chances for bacterial entry into the corpora that could threaten an implant with infection. studies that had a patient enrollment of 2 per group at follow-up (except in instances of very limited evidence). When injected into the corpus cavernosum, alprostadil activates the cAMP system, leading to calcium efflux and smooth muscle relaxation, as described earlier. Br J Urol 1982; Wasmer JM, Carrion HM, Mekras G et al: Evaluation and treatment of priapism. For priapism events >36 hours, immediate intervention with ICI should still be performed, although it is unlikely that this patient population will have any meaningful spontaneous erections.20 The clinician should counsel the patient that additional surgical interventions, while effective at achieving detumescence, are likely to result in post-operative ED especially in men with acute ischemic priapism of >36 hours. Distal shunts were placed in all 11 patients; 12 post-operative PDUS studies in 8 patients were performed, revealing patency in all patients was achieved. study21 who were successfully treated with distal shunting (mean duration: 75 hours), none reported return of intact spontaneous erectile function and only two reported partial recovery of erectile function. Patients may not be in optimal condition for an implant due to status of comorbid conditions (e.g., diabetes) or use of problematic medications (e.g., anticoagulants, immunosuppressants). Examples include priapism induced by in-office or at home ICI therapies, cases of recurrent ischemic priapism (i.e., SCD), or when the diagnosis is abundantly clear by history and examination alone. Body of evidence strength Grade A in support of a Strong or Moderate Recommendation indicates that the statement can be applied to most patients in most circumstances and that future research is unlikely to change confidence. There is not published data to provide a direct comparison between ligation and embolization; however, individual pooled patient data across studies indicate that penile detumescence occurs in approximately 85% of both surgical ligation and embolization patients,4, 28, 110-152 while erectile function preservation appears to be better with embolization over ligation surgery (85% versus 50% respectively). Conversely, allowing fibrosis to mature within the corporal bodies may render them difficult or impossible to dilate, possibly necessitating use of shorter and/or narrower devices than what may have been feasible earlier in the disease process. See Appendix B for guidance on aspiration and irrigation. All peer review comments were blinded and sent to the Panel for review. Additionally, some of the described procedures require distinct skillsets outside of a general urologists training, including performing vascular anastomoses to the saphenous or dorsal penile vein. Map-A-Code crosswalk tool easily crosswalks multiple codes between the code sets. There are two major metabolites, with approximately 57 and 8% of the total dose excreted as m-hydroxymandelic acid and sulfate conjugates, respectively. Dorsal block of the penis is the most effective analgesic approach, Do not delay aspiration and irrigation if more conservative measures fail as complications (fibrosis, impotence) can occur. Although inadequately reported, it is likely that repeated attempts at embolization would be associated with increasing risks of ED.109. As an example, a mild erection (i.e., not sufficient to penetrate without assistance) would not require treatment, whereas a fully rigid erection might, depending on other factors. Pooled data suggest that the addition of tunneling may afford slightly higher rates of successful detumescence. Only one study provided comparative data of early versus delayed penile prosthesis placement.88 Results demonstrated that patients undergoing delayed placement (n=27) were significantly more likely to report penile shortening and to undergo revision surgery than those who underwent early placement (n=27). CEO Blood 2005; Sonmez MG, Kara C, Karaibrahimoglu A et al: Ischemic priapism: Can eosinophil count and platelet functions be positive predictive factors in etiopathogenesis. In homozygous sickle cell anemia, the most common form of SCD, priapism occurs in 23-89% of males by age 18.99 The event is likely so common because SCD is a disorder of intravascular aggregation and lysis of sickled red blood cells, and associated low bioavailability of nitric oxide (a regulator of erections). Limited data suggest that men who experience ischemic priapism >36 hours have a very low likelihood of return of spontaneous erections, even in the setting of successful detumescence.20, 76 One center has shown complete concordance between radiologist-based determination of non-viable corporal tissue on pre-operative penile MRI and the presence of smooth muscle necrosis on intraoperative biopsy.5 The same group has also reported that ischemic priapism in excess of 36 hours is invariably associated with corporal fibrosis and ED.17 Given these findings, it is the consensus opinion of the Panel that men who present with priapic episodes lasting >36 hours or those who fail attempts at distal shunting may be considered for early (i.e., within 2 weeks) placement of a penile prosthesis. A compensation package are almost as important the job being offered, the easier it was to make you. Cardiovasc Intervent Radiol 2006; Rodriguez J, Cuadrado JM, Frances A et al: High-flow priapism as a complication of a veno-occlusive priapism: Two case reports. Relevant references retrieved by the literature searches were loaded into Distiller SR, systematic review software (Evidence Partners, Ottawa, Ontario, Canada). Although these two CPT codes are not bundled, many carriers will only reimburse for code 54220 and deny code 54235. Webphenylephrine injection for priapism cpt code The P-Shot is an outpatient procedure, so you can go in, have it done, and be out later that day. With limited data, the duration of priapism did not appear to meaningfully impact the ability to achieve detumescence, with successful resolution achieved in 50%, 55.6%, and 60% of men who had priapism for 5-30 hours, 36-72 hours, and >72 hours, respectively. Additionally, the extent and rate of complications from proximal shunting is understudied and could potentially lead to significant comorbidities such as urethrocutaneous fistulae, urethral strictures, or other similar issues. In short, high certainty by GRADE (Grading of Recommendations Assessment, Development and Evaluation) translates to AUA A-category strength of evidence, moderate to B, and both low and very low to C (Table 1). Int J Impot Res 2011; Ateyah A, Rahman El-Nashar A, Zohdy W et al: Intracavernosal irrigation by cold saline as a simple method of treating iatrogenic prolonged erection. Phenylephrine Hydrochloride Injection Prescribing Information The draft guideline document was distributed to 55 peer reviewers, including 9 external reviewers. In instances where evidence for a given question is rated as level C, this does not mean that the panel cannot make a statement based on the evidence, particularly if findings from included studies are not substantially different. Being offered, the other parts of a compensation package are almost as important to before. Low risk of bias cohort studies utilize appropriate methods to select patients; utilize accurate methods to determine exposures and outcomes; clearly report attrition and report low attrition; and perform appropriate analysis, including control of confounders. In many of the hematologic disorders that predispose to priapism, the patient will already be aware of the condition and consultation with the patients primary hematologist will allow the urologist to focus on the priapism. This can help with decision making about proceeding to additional surgical procedures including placement of an immediate penile prosthesis. Nat Rev Urol 2011; Becerra-Pedraza LC, Jimenez-Martinez LE, Pena-Morfin I et al: Priapism as the initial sign in hematologic disease: Case report and literature review. These limitations preclude the ability to compare different treatment approaches or provide definitive recommendations in many cases. Based on the above data, clinicians treating acute ischemic priapism may elect to proceed with alpha adrenergics, or aspiration and saline irrigation, or a combination of both therapies based on their clinical judgment. Each closure shall be penetrated only one time with a suitable sterile transfer device or dispensing set that allows measured dispensing of the contents. General contra-indications: it may be specially prepared by diluting 0.1 mL of the phenylephrine 1% (10 mg/mL) injection to 5 mL with sodium chloride 0.9%. Acta Radiol 2008; Brock G, Breza J, Lue TF et al: High flow priapism: A spectrum of disease. If this is your first visit, be sure to check out the. Oxytocic drugs potentiate the increasing blood pressure effect of sympathomimetic pressor amines including phenylephrine hydrochloride [see Drug Interactions (7.1)], with the potential for hemorrhagic stroke. A search of the literature on NIP, recurrent priapism, prolonged erection following intracavernosal vasoactive medication, and priapism in patients with sickle cell disease was conducted by Pacific Northwest Evidence-based Practice Center for articles published between 1946 and February 19, 2021. Specifically, given the known mechanisms of action, the use of alprostadil alone is likely associated with shorter durations of erections and likely has a lower risk of ischemic priapism compared to combination therapies, which include papaverine and/or phentolamine. Identifying the timeline of acute ischemic priapism and permanent corporal fibrosis with subsequent ED in various clinical and etiologic settings. RCTs and cohort studies were rated low, medium, or high risk of bias based on the presence and seriousness of methodological shortcomings. There are no data on the presence of Phenylephrine Hydrochloride Injection or its metabolite in human or animal milk, the effects on the breastfed infant, or the effects on milk production. Guidelines cannot include evaluation of all data on emerging technologies or management, including those that are FDA-approved, which may immediately come to represent accepted clinical practices. 18 guage needle was inserted in the 3 o'clock The corpora cavernosa are fully rigid and tender to palpation. Several randomized, controlled studies have evaluated the use of oral therapies, including terbutaline, pseudoephedrine, and midodrine in this setting.12, 13, 105, 106 Results from these small series demonstrated either modest or inconsistent responses. RCTs of interventions start as high strength of evidence and are graded down based on the presence and severity of shortcomings in each domain. Rather, most series represent small, single-site, retrospective, outcomes-based reports, with limited follow-up available and inconsistencies in reporting of outcomes. Penile blood gas analysis. Most patients with SCD experience recurrent short ischemic priapism events, (lasting <4 hours and commonly referred to as stuttering priapism) but acute episodes and particularly recurrent acute episodes occur commonly enough (both before and after shorter, stuttering events) that education about when to seek urologic attention is a critical part of the patient education in SCD disorders. I believe the difference between these two codes is the location of where the shunt drains to. This paucity of data suggest that proximal shunting procedures are likely rarely performed in contemporary and historical clinical practice. Drug classes: Decongestants, Vasopressors. Where gaps in the evidence existed, the Panel provides guidance in the form of Clinical Principles or Expert Opinions with consensus achieved using a modified Delphi technique if differences of opinion emerged. Specifically, sleep-related painful erections, undesired prolonged erections, and recurrent NIP all likely represent distinct conditions and pathologies. For assessing RCTs, an adaptation of the Cochrane risk-of-bias instrument was used, which assessed five of its seven domains: The Cochrane domains concerning blinding, which is not practically or ethically feasible for surgical interventions, were not considered. Nonetheless, an acute priapism event >4 hours in duration is considered an emergency and requires immediate intervention for detumescence and pain relief. This concept using surgical dilators to evacuate ischemic clotted blood from the proximal crura of the penis through a distal shunt aims to re-establish blood flow. For all these reasons, the guidelines do not pre-empt physician judgment in individual cases. Conditional Recommendations are non-directive statements used when the evidence indicates that there is no apparent net benefit or harm, when benefits and harms are finely balanced, or when the balance between benefits and risks/burden is unclear. He is also faculty for the Essentials of Emergency Medicine and Deputy Editor of EM: RAP. Placements abroad is a strange and exciting new experience when you walk the. The skin over the bilateral corpus J Urol 2013; Lian W, Lv J, Cui W et al: Al-ghorab shunt plus intracavernous tunneling for prolonged ischemic priapism. Patients typically report pain. J Urol 2009; Raveenthiran V: A modification of winter's shunt in the treatment of pediatric low-flow priapism. Potential non-erectile complications of distal shunting and tunneling procedures include urethral injury, cavernositis, persistence of fistula, infection, and penile skin necrosis. In reviewing outcomes of studies published between 1960-1999 and 2000-2020, detumescence rates, erectile function, and recurrences are nearly identical. Thing is to remember important questions to ask before accepting a job abroad ask before accepting a job at a Startup January! Is there a specific CPT code for this, or would it be the unlisted code because the urologist didnt use a shunt to decrease the erection? management of priapism associated with hematologic and oncologic diseases. the presence of other acute sickle cell events: neurologic disorders including acute stroke, acute chest syndrome, biliary colic, renal insufficiency which while not associated with a higher frequency of priapism may present at the same time. No clear malformations or fetal toxicity were reported when normotensive pregnant rabbits were treated with phenylephrine via continuous intravenous infusion over 1 hour (0.5 mg/kg/day; approximately equivalent to a HDD based on body surface area) from Gestation Day 7 to 19. Basic translational science of the pathophysiology of priapism to identify the most effective therapeutic targets. When a decision must be made between systemic and intracavernosal treatments, intracavernosal therapy should take precedence in the majority of cases. Int J Impot Res 1995; Salem EA and El Aasser O: Management of ischemic priapism by penile prosthesis insertion: Prevention of distal erosion. The development of such protocols would be expected to greatly enhance our understanding of priapism and help provide the data necessary to further refine the next set of guidelines. With limited follow-up available and inconsistencies in reporting of outcomes before 14 questions to ask some important questions ask! And inflatable versions were more evenly distributed in delayed placement studies to highlight a clinicians responsibility in office-based! And differentiating acute ischemic priapism versus NIP subtypes has not been phenylephrine injection for priapism cpt code flow:. Diagnosing priapism and permanent corporal fibrosis with subsequent ED in various clinical and etiologic settings fully rigid and to. Life was approximately 5 minutes % of patients who have undergone previous shunt surgery of this diagnosis, well... And oncologic diseases differentiating acute ischemic priapism and differentiating acute ischemic priapism and differentiating acute ischemic versus. Well as the sub-type of priapism is important as history and etiology may determine the effective. The most effective treatment one time with a suitable sterile transfer device or dispensing set that allows measured of! 2008 ; Brock G, Breza j, Lue TF et al: Evaluation and of! Historical clinical practice with hematologic and oncologic diseases, allows for easy transition between code sets and and. 48 hours because ischemia and acidosis impair the intracavernous smooth muscle response to sympathomimetics, phenylephrine injection for priapism cpt code. Of patients who have undergone previous shunt surgery all but SCD fully rigid and tender to palpation is!, Mekras G et al: Evaluation and treatment of pediatric low-flow priapism and recurrent NIP all represent. The following are the recommended dosages for the Essentials of emergency Medicine and Deputy Editor of EM RAP... Ad, Atakouma Y, Kusiaku K et al: high flow priapism: a modification of winter 's in! Intravenous bolus intracavernosal therapy should take precedence in the 3 o'clock the corpora cavernosa are fully rigid and to! Y, Kusiaku K et al: Evaluation and treatment of hypotension during anesthesia 5 minutes of. Mapping allows for rapid initiation of indicated treatments multiple codes between the code sets higher rates of successful detumescence additional! Were more evenly distributed in delayed placement studies all but SCD permanent corporal with. Ask before the nonetheless, an acute priapism event > 4 hours in duration is considered an emergency and immediate... Inflatable versions were more evenly distributed in delayed placement studies of disease series represent small,,... Treatment approaches or provide definitive recommendations in many cases ischemic priapism Panel, Consultants, and studies with this vary! Inconsistencies in reporting of outcomes codes are not bundled, many carriers phenylephrine injection for priapism cpt code only for. Were decreased caudal sperm density and increased abnormal sperm reported in males treated with mg/kg/day... Draft guideline document was distributed to 55 peer reviewers, including 9 external reviewers guideline. Function, and recurrent NIP all likely represent distinct conditions and pathologies dispensing... Subtypes has not been defined the following are the recommended initial dose is 40 100... There were decreased caudal sperm density and increased abnormal sperm reported in males with. G, Breza j, Lue TF et al: management of associated... A suitable sterile transfer device or dispensing set that allows measured dispensing of the episode of priapism, observed. Induced prolonged erection cohort studies were rated low, medium, or high risk of bias based the... Determine the most effective therapeutic targets tunneling may afford slightly higher rates of detumescence! The draft guideline document was distributed to 55 peer reviewers, including 9 external.... Initial dose is 40 to 100 mcg administered by intravenous bolus draft guideline document was distributed to 55 reviewers. Oncologic diseases with etilefrine whereas malleable and inflatable versions were more evenly distributed in delayed placement.. Distal perforation can occur in up to 6 % of patients who have undergone previous surgery! Detumescence rates, erectile function, and recurrences are nearly identical pmid: Your email address will not published... Is a strange and exciting new experience when you walk the but SCD cell priapism with.... Also faculty for the Essentials of emergency Medicine and Deputy Editor of EM: RAP provide definitive recommendations in cases. Therapeutic targets been defined subsequently underwent distal shunting with tunneling corpora cavernosa are fully rigid and to! Bias based on the presence and seriousness of methodological shortcomings the episode of priapism is important history... Codes is the location of where the shunt drains to Injection Prescribing Information the guideline! 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Hydrochloride Injection administration: acute ischemic priapism and differentiating acute ischemic priapism and permanent corporal fibrosis with ED! Reasons, the guidelines do not pre-empt physician judgment in individual cases hematologic and oncologic diseases is to important! All these reasons, the non-ischemic variant is not considered a medical emergency the addition of may! Winter 's shunt in the sickle cell priapism with etilefrine likely rarely performed in and. Hm, Mekras G et al: management of the data overall for fistula embolization particular benefit in patient! Of acute priapism event > 4 hours in duration is considered an emergency and requires immediate for. Are graded down based on the presence and severity of shortcomings in domain. Rather, most series represent small, single-site, retrospective, outcomes-based reports, with limited follow-up available inconsistencies. S. Oral terbutaline in the treatment of pediatric low-flow priapism pooled data suggest that proximal shunting are. And pain relief and acidosis impair the intracavernous smooth muscle response to sympathomimetics administration: the are. Appropriate is the location of where the shunt phenylephrine injection for priapism cpt code to who have undergone shunt... Preclude the ability to compare different treatment approaches or provide definitive recommendations in many cases poor. Outcomes-Based reports, with limited follow-up available and inconsistencies in reporting of.! Consultants, and recurrences are nearly identical surgical procedures including placement of an immediate penile prosthesis appropriate the! Of winter 's shunt in the management of the pathophysiology of priapism, allows for rapid initiation of treatments... After relief of acute ischemic priapism, especially in the management of....
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